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Press release: Predicting the optimal lymphatic drug delivery method (LDDS) based on osmotic pressure, viscosity, and lymph node size – Using AI and mathematical models to provide lymph node therapy aligned with treatment strategies.

2026.05.29 Press release


A press release was issued for a paper published in The Journal of Controlled Release by Mr. Reito Miyazaki, Master’s student, and colleagues.

Tohoku University website (May 29, 2026)

Our laboratory has developed an AI-based mathematical modeling platform that predicts optimal treatment conditions for lymphatic drug delivery system (LDDS) based on the osmotic pressure, viscosity, and lymph node size of the drug formulation.

These findings are expected to contribute to the development of personalized treatment strategies for lymph node metastasis.

Publication Details:
Title: Model-guided Design of Lymphatic Drug Delivery Systems Using
Osmotic Pressure, Viscosity and Lymph Node Size
Authors: Reito Miyazaki, Ariunbuyan Sukhbaatar, Shiro Mori, Takahiro Kusaka,
Katsunori Katagiri, Kiyoto Shiga, Tetsuya Kodama*
Journal: The Journal of Controlled Release
DOI:10.1016/j.jconrel.2026.115010