Research Area

• Natural product chemistry, Dynamic bioorganic chemistry
• Research for novel bioactive natural product playing a key role
• Structural determination of novel bioactive natural polysaccharide
• Chemistry of interaction between bioactive ligand and their receptor
• Chemical biology using synthetic bioactive probe

Overview of Research

The chemical studies on the biological phenomenon are a dream of natural products chemist for a long time. We carry out the research on "the dynamic aspects of natural product chemistry" for the physiologically intriguing phenomenon of "action of the plant " which fascinated many big scientists such as C. Darwin and J. H. Fabre.
In our laboratory, organic chemistry for biological phenomenon that is controlled by biological clock has been developed. This research requires the scientific approach of the wide utilization of various techniques in natural product chemistry, such as isolation of bioactive substance, organic synthetic chemistry, and biochemical handlings of the cell and protein. Our aims are focused on the research result that remains for long time in the history of science in the world.

Selected Publications

• H. Saito, T. Oikawa, S. Hamamoto, Y. Ishimaru, T. Utsumi, J. Chen, M. Kanamori, Y. Sasaki-Sekimoto, M. Shimojima, S. Masuda, Y. Kamiya, M. Seo, N. Uozumi, M. Ueda, H. Ohta, A The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis, Nature Commun. 6: 6095 doi: 10.1038/ncomms7095 (2015).
• M. Ueda, G. Yang, Y. Nukadzuka, Y. Ishimaru, S. Tamura, Y. Manabe, Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity,Org. Biomol. Chem., 13, 55-58 (2015).
• S. Tamura, S. Inomata, M. Ebine, T. Genji, I. Iwakura, M. Mukai, M. Shoji, T. Sugai, M. Ueda, Triazoyl-Phenyl Linker System Enhancing Aqueous Solubility of Molecular Probe and Efficiency in Affinity Labeling of Target Protein for Jasmonate Glucoside, Bioorg. Med. Chem. Lett. 23, 188-193 (2013).
• M. Ueda, Y. Manabe, Y. Otsuka, N. Kanzawa, Cassia occidentalis MetE as a cytosolic target for potassium isolespedezate, a leaf-opening factor of Cassia plants: target exploration by compact molecular probe (CMP) strategy, Chem. Asian J. , 6, 3287-3297 (2011).
• Y. Nakamura, A. Mithöfer, E. Kombrink, W. Boland, S. Hamamoto, N. Uozumi, K. Tohma, M. Ueda, 12-Hydroxyjasmonic Acid Glucoside is a COI1-JAZs Independent Activator of Leaf Closing Movement in Samanea saman, Plant Physiol., 155, 1226-1236 (2011).

Contact Information

“Please delete “/” after “@” in a mail address.”
Minoru UEDA
(TEL/FAX +81-22-795-6553, Email: ueda@/m.tohoku.ac.jp)
Yousuke TAKAOKA
(TEL/FAX +81-22-795-6557, Email: ytakaoka@/m.tohoku.ac.jp)
Takuya KAJI
(TEL/FAX +81-22-795-6557, Email: takuya.kaji.c6@tohoku.ac.jp)
Website: http://www.orgchem1.chem.tohoku.ac.jp/orgchem1/Home.html