Staff

• Professor
  Hitoshi KASAI
• Lecturer
  Kouki OKA
• Assistant Professor
  Hiroi SEI

Research Themes

• Fabrication of size-controlled organic nanoparticles
• Creation of new-designed anti-cancer nanodrugs and their pharmacological activities
• Preparation of nano eye drops and their pharmacological activities
• Synthesis of drug compounds by using bio-process
• Functionalization of pigments derived from organism by forming nanoparticles
• Creation of hybrid nanoparticles incorporating precious metals for drug delivery systems

Selected Publications

1. "A Method for Enhancing The Ocular Penetration of Eye Drops Using Nanoparticles of Hydrolyzable Dye", K. Baba, Y. Tanaka, A. Kubota, H. Kasai, S. Yokokura, H. Nakanishi, K. Nishida＊, J. Control Release, 153, 278–287 (2011).
2. “Creation of Pure Nanodrugs and Their Anticancer Properties“, H. Kasai＊, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida,, Angew. Chem. Int. Ed., 51, 10315–10318 (2012).
3. “Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity”, Y. Koseki, Y. Ikuta, L. Cong, M. Takano, H. Tada, M. Watanabe, K. Gonda, T. Ishida, N. Ohuchi, K. Tanita, F. Taemaitree, A. T.N. Dao, T. Onodera, H. Oikawa, H. Kasai＊,　Bull. Chem. Soc. Jpn., 92, 1305–1313 (2019).
4. “FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery”, F. Taemaitree, B. Fortuni＊, Y. Koseki, E. Fron, S. Rocha, J. Hofkens, H. Uji-i, T. Inose and H. Kasai＊, Nanoscale, 2020, 12, 16710–16715.
5. “Carrier-free Nano-prodrugs for Minimally Invasive Cancer Therapy“, K. Tanita, Y. Koseki＊, S. Kumar, F. Taemaitree, A. Mizutani, H. Nakatsuji, R. Suzuki, A. T. N. Dao, F. Fujishima, H. Tada, T. Ishida, K. Saijo, C. Ishioka, H. Kasai＊, Nanoscale, 16, 15256–15264 (2024).136, 7201-7204 (2014).

Contact Information

(Please delete "/" after "@" in a mail address.)
Prof. Hitoshi KASAI
(TEL +81 22-217-5612, Email: kasai@/tohoku.ac.jp)
Website: https://www2.tagen.tohoku.ac.jp/lab/kasai/