Research Area
- Nano/Micro Chemical Measurements
Research Subjects
- Easy and automated chemical analysis utilizing nano/microfluidic device.
- Liquid-film separation / preconcentration method based on interface chemistry.
- Physicochemical analysis of amyloid nucleation in biofluids.
Overview of Research
We study advanced nano-micro technologies in chemistry and biochemistry and their applications to integrated analytical devices. We investigate easy and automated analytical technologies for life science, environmental science, food safety, and industrial process. We also investigate novel analytical technologies such as single cell analysis, single molecule analysis, single event analysis, and molecular behavior in rapid mixing. For the advanced technologies, fundamental chemistry such as chemical reaction, phase transfer, and phase separation in a confined space should be revealed in detail. We study unique advanced measurement tools such as microscopic imaging, laser microscopy, and microfluidics.
Selected Publications
- Detection of fibril nucleation in micrometer-sized protein condensates and suppression of Sup35NM fibril nucleation by liquid-liquid phase separation
Fukuyama, Mao, Nishinami, Suguru, Maruyama, Yoko, Ozawa, Taiki, Tomita, Shunsuke, Ohhashi, Yumiko, Kasuya, Motohiro, Gen, Masao, Chatani, Eri, Shiraki, Kentaro, Hibara, Akihide, Analytical Chemistry, 95, 26, 9855–9862 (2023).
- Nanoparticle Assembly at the Water–Oil Interface Induced by Spontaneous Emulsification for Microdroplet Immunoassay
Mao Fukuyama, Kotone Kubota, Akihide Hibara,Langmuir, 39, 22, 7884-7890 (2023).
- Microfluidic protein crystallisation controlled using spontaneous emulsification M. Fukuyama, A. Akiyama, M. Harada, T. Okada, A. Hibara, Analytical Methods, 7, 7128-7131 (2015).
- Controlling Water Transport Between Micelles and Aqueous Microdroplets during Sample Enrichment
Mao Fukuyama, Lin Zhou, Tetsuo Okada, Kristina V, Simonova, Mikhail Proskurnin, Akihide Hibara
Analytica Chimica Acta, 1149(1) 338212 (2021).
- Non-Competitive Fluorescence Polarization Immunoassay for Protein Determination,
Mao Fukuyama, Ayano Nakamura, Keine Nishiyama, Imai Ayuko, Manabu Tokeshi, Koji Shigemura and Akihide Hibara
Analytical Chemistry, 92(21) 14393-14397 (2020).
- Microfluidic Selective Concentration of Microdroplet Contents by Spontaneous Emulsification M. Fukuyama, A. Hibara, Analytical Chemistry, 87, 3562-3565 (2015).
Contact Information
“Please delete “/” after “@” in a mail address.”
Mao FUKUYAMA
(TEL 022-217-5396, Email: maofukuyama@/tohoku.ac.jp)
Homepage: https://www2.tagen.tohoku.ac.jp/lab/hibara/html/index.html
