MEMBER

阿部 博弥
准教授
【生体計測】・バイオセンサー、・マイクロナノ電気化学デバイス
マイクロ・ナノサイズの電気化学センサーは生体試料の代謝等の状態を、電極上で起こる酸化還元反応を計測することで非標識で局所的に評価できる手法です。私は、チップ型やプローブ型の電気化学デバイスを使った数百µm程度の細胞組織モデルを対象とした局所解析を行ってきました。本部門では、化粧品や医薬部外品の開発・評価に特化した局所解析デバイスを設計し、さらに多様なバックグラウンドの研究者と連携することで、新たな視点からのバイオセンシングを目指します。
研究論文
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Analytical Chemistry 2024
"Extended Spherical Diffusion Theory: Electrochemiluminescence Imaging Analysis of Diffusive Molecules from Spherical Biosamples"
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NPG Asia Materials 16(1) 2024
"Mussel-inspired thermo-switchable underwater adhesive based on a Janus hydrogel"
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ACS Sensors 2024
"Enzyme-Free In-Situ Electrochemical Measurement Using a Porous Membrane Electrode for Glucose Transport into Cell Spheroids"
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Advanced Functional Materials 34(2) 2023
"Spatiotemporally Controllable Chemical Delivery Utilizing Electroosmotic Flow Generated in Combination of Anionic and Cationic Hydrogels"
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Polymer Journal 55(11) 1231 -1236 2023
"Mussel-inspired interfacial ultrathin films for cellular adhesion on the wrinkled surfaces of hydrophobic fluids"
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Analytical Chemistry 95(17) 6791 -6800 2023
"The Development of Aptamer-Coupled Microelectrode Fiber Sensors (apta-μFS) for Highly Selective Neurochemical Sensing"
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Journal of Controlled Release 354 694 -700 2023
"Frustoconical porous microneedle for electroosmotic transdermal drug delivery"
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Advanced Healthcare Materials 11(23) 2201627 -2201627 2022
"Totally Organic Hydrogel-Based Self-Closing Cuff Electrode for Vagus Nerve Stimulation"
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Microelectronic Engineering 265 111877 -111877 2022
"Intradermal measurement of reactive oxygen species using open-tip porous microneedles"
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Biosensors 12(8) 559 -559 2022
"Thermally Drawn CNT-Based Hybrid Nanocomposite Fiber for Electrochemical Sensing"
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Advanced NanoBiomed Research 2(1) 2100066 -2100066 2022
"Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines"
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Macromolecular Materials and Engineering 306(9) 2100171 -2100171 2021
"Biodegradable Porous Microneedles for an Electric Skin Patch"
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Electrochem 2(3) 472 -489 2021
"Light in Electrochemistry"
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Langmuir 37(20) 6201 -6207 2021
"Bio-inspired Incrustation Interfacial Polymerization of Dopamine and Cross-linking with Gelatin toward Robust, Biodegradable Three-Dimensional Hydrogels"
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Nature Communications 12(1) 658 2021
"Transdermal electroosmotic flow generated by a porous microneedle array patch"
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Analyst 145(21) 6895 -6900 2020
"Bioimaging using bipolar electrochemical microscopy with improved spatial resolution"
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Biomedical Microdevices 22(3) 57 2020
"Totally transparent hydrogel-based subdural electrode with patterned salt bridge"
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Sensors and Actuators B: Chemical 304 127245 -127245 2020
"Redox cycling-based electrochemical CMOS imaging sensor for real time and selective imaging of redox analytes"
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Electroanalysis 30(12) 2841 -2846 2018
"Simultaneous and Selective Imaging of Dopamine and Glutamate Using an Enzyme-modified Large-scale Integration (LSI)-based Amperometric Electrochemical Device"
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Chemistry Letters 47(7) 843 -845 2018
"Chemical imaging using a closed bipolar electrode array"
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Analytical Chemistry 89(23) 12778 -12786 2017
"Electrochemicolor Imaging Using an LSI-Based Device for Multiplexed Cell Assays"
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Electrochemistry 84(5) 364 -367 2016
"Electrochemical imaging for single-cell analysis of cell adhesion using a collagen-coated large-scale integration (LSI)-based amperometric device"
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Biosensors and Bioelectronics 77 709 -714 2016
"Potentiometric bioimaging with a large-scale integration (LSI)-based electrochemical device for detection of enzyme activity"
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Analytical Chemistry 87(12) 6364 -6370 2015
"Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors"