We are pleased to share that our recent study has been published in Scientific Reports and featured in a press release by Tohoku University.
In this work, we developed a new non-invasive cancer hyperthermia therapy by combining magnetic nanoparticles with a lymphatic drug delivery system (LDDS). Using a mouse metastasis model, we demonstrated that controlled magnetic heating can suppress tumor progression in lymph nodes and lung metastasis while minimizing adverse effects.

🔹 Key Findings
Development of a temperature-controlled magnetic hyperthermia system
Significant inhibition of tumor growth in lymph nodes and lungs
Reduced systemic toxicity, offering a potential alternative to lymph node dissection
A novel therapeutic concept utilizing nanoparticles + lymphatic delivery

Press Release (Tohoku University, November 28, 2025)
[https://lnkd.in/gdSCsRXD
DOI: 10.1038/s41598-025-25808-5

Publication Details:

Title: Magnetic hyperthermia using iron oxide nanoparticles via LDDS suppressed lymph node and lung metastasis in a mouse model
Authors: Akihiro Kuwahata, Ariunbuyan Sukhbaatar, Akihiro Shikano, Loi Tonthat, Takayuki Kagami, Riku Shinohara, Shiro Mori, Shin Yabukami*, and Tetsuya Kodama*
Journal:Scientific Reports
DOI: 10.1038/s41598-025-25808-5