{"id":518,"date":"2024-10-23T00:00:00","date_gmt":"2024-10-22T15:00:00","guid":{"rendered":"https:\/\/web.tohoku.ac.jp\/diare\/?post_type=news&#038;p=518"},"modified":"2026-10-15T14:54:48","modified_gmt":"2026-10-15T05:54:48","slug":"news-518","status":"publish","type":"news","link":"https:\/\/web.tohoku.ac.jp\/diare\/news\/news-518\/","title":{"rendered":"\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308a\u3046\u308b\u7d30\u80de\u5185\u306e\u9846\u7c92\u306e\u7d30\u80de\u5185\u5b9a\u91cf\u306b\u6210\u529f \uff5e\u751f\u304d\u305f\u7d30\u80de\u5185\u306e\u76f8\u5206\u96e2\u6db2\u6ef4\u306f\u5fc5\u305a\u3057\u3082\u5bc6\u306a\u69cb\u9020\u3067\u306f\u306a\u3044\uff5e"},"content":{"rendered":"<p>\u4e2d\u6797\u5b5d\u548c\u6559\u6388\u3001\u535a\u58eb\u6559\u80b2\u9662\u751f\u306e\u6f81\u8c37 \u84ee \u3055\u3093\uff08\u85ac\u5b66\u7814\u7a76\u79d1\u30fb\u5206\u5b50\u85ac\u79d1\u5b66\u5c02\u653b\u30fbD1) \u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308a\u3046\u308b\u7d30\u80de\u5185\u306e\u9846\u7c92\u306e\u7d30\u80de\u5185\u5b9a\u91cf\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u3010\u767a\u8868\u306e\u30dd\u30a4\u30f3\u30c8\u3011<\/p>\n<ul>\n<li>\u00a0ALS\uff08\u6ce81\uff09\u3084\u304c\u3093\u306e\u5275\u85ac\u6a19\u7684\u3068\u3055\u308c\u308b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\uff08\u6ce82\uff09\u306b\u3064\u3044\u3066\u3001\u5185\u90e8\u306e\u5316\u5b66\u7d44\u6210\u3001\u5206\u5b50\u69cb\u9020\u3001\u6fc3\u5ea6\u3092\u3001\u751f\u304d\u305f\u7d30\u80de\u5185\u3067\u5b9a\u91cf\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/li>\n<li>\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5185\u90e8\u306f\u9ad8\u5ea6\u306b\u6fc3\u7e2e\u3055\u308c\u305f\u5bc6\u306a\u74b0\u5883\u3067\u306f\u306a\u304f\u3001\u9846\u7c92\u306e\u5468\u56f2\u3068\u540c\u7a0b\u5ea6\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u5468\u56f2\u3088\u308a\u3082\u758e\u306a\u74b0\u5883\u306b\u306a\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/li>\n<li>\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306a\u3069\u306e\u76f8\u5206\u96e2\u6db2\u6ef4\uff08\u9846\u7c92\uff09\u306e\u5b9a\u91cf\u7684\u306a\u7406\u89e3\u304c\u6df1\u307e\u308b\u3053\u3068\u3067\u3001\u6db2\u6ef4\u3092\u4ecb\u3057\u305f\u75be\u60a3\u306e\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u3084\u5275\u85ac\u3078\u306e\u5c55\u958b\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/li>\n<\/ul>\n<p>\u3010\u6982\u3000\u8981\u3011<br \/>\n\u6db2-\u6db2\u76f8\u5206\u96e2\u73fe\u8c61\uff08\u6ce83\uff09\u306b\u3088\u3063\u3066\u7d30\u80de\u5185\u3067\u5f62\u6210\u3055\u308c\u308b\u751f\u4f53\u5206\u5b50\u306e\u6fc3\u539a\u76f8\uff08\u6db2\u6ef4\uff09\u306f\u3001\u819c\u306e\u306a\u3044\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u3068\u547c\u3070\u308c\u3001\u7d30\u80de\u306e\u533a\u753b\u5316\u3084\u53cd\u5fdc\u5834\u306e\u63d0\u4f9b\u306a\u3069\u69d8\u3005\u306a\u5f79\u5272\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u6db2\u6ef4\u5185\u306b\u3042\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7570\u5e38\u51dd\u96c6\u306b\u3088\u308a\u3001ALS \u3084\u304c\u3093\u7b49\u3092\u5f15\u304d\u8d77\u3053\u3059\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u3082\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1\u306e\u6f81\u8c37\u84ee\u5927\u5b66\u9662\u751f\u3001\u68b6\u672c\u771f\u53f8\u51c6\u6559\u6388\u3001\u4e2d\u6797\u5b5d\u548c\u6559\u6388\u3089\u306f\u3001\u30e9\u30de\u30f3\u9855\u5fae\u93e1\uff08\u6ce84\uff09\u3068\u547c\u3070\u308c\u308b\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u6db2-\u6db2\u76f8\u5206\u96e2\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u305f\u751f\u7d30\u80de\u5185\u306e\u5358\u4e00\u6db2\u6ef4\u3092\u305d\u306e\u5834\u3067\u5b9a\u91cf\u8a55\u4fa1\u3059\u308b\u624b\u6cd5\u3092\u63d0\u6848\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u7d30\u80de\u5185\u6db2\u6ef4\u306e\u4e00\u3064\u3067\u3042\u308b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u3092\u6e2c\u5b9a\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5185\u90e8\u306e\u6838\u9178\u6fc3\u5ea6\u3092\u305d\u306e\u5834\u3067\u6e2c\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u5185\u5916\u306e\u751f\u4f53\u5206\u5b50\u306e\u6fc3\u5ea6\u74b0\u5883\u3092\u5b9a\u91cf\u7684\u306b\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306f\u5fc5\u305a\u3057\u3082\u5bc6\u306a\u69cb\u9020\u3067\u306f\u306a\u3044\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002 \u672c\u624b\u6cd5\u306f\u3042\u3089\u3086\u308b\u7d30\u80de\u5185\u6db2\u6ef4\u306e\u5206\u6790\u306b\u9069\u7528\u53ef\u80fd\u3067\u3042\u308a\u3001\u6db2\u6ef4\u3068\u69d8\u3005\u306a\u751f\u7406\u73fe\u8c61\u3084\u75be\u60a3\u3068\u306e\u95a2\u4fc2\u306e\u89e3\u660e\u3001\u5275\u85ac\u3078\u306e\u5c55\u958b\u306a\u3069\u5e45\u5e83\u3044\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002 \u672c\u6210\u679c\u306f 2024 \u5e74 10 \u6708 15 \u65e5 (\u706b) \u306b\u30a2\u30e1\u30ea\u30ab\u5316\u5b66\u4f1a\u306e\u5b66\u8853\u8a8c Analytical Chemistry \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.tohoku.ac.jp\/japanese\/newimg\/pressimg\/item20241023_02_cell.jpg\" \/><\/p>\n<div class=\"withCaption\">\n<p>\u56f31. \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8ca0\u8377\u3057\u305f\u7d30\u80de\u306e (A) \u8fd1\u8d64\u5916\u86cd\u5149\u753b\u50cf\u3068 (B~D) \u5bfe\u5fdc\u3059\u308b\u30e9\u30de\u30f3\u753b\u50cf\u3002\u5404\u30e9\u30de\u30f3\u753b\u50cf\u306f (B) \u6838\u9178\u3001 (C) \u8102\u8cea\u3001 (D) \u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u5e03\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>\u3010\u7528\u8a9e\u89e3\u8aac\u3011<\/p>\n<p>\u6ce81. ALS<br \/>\n\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08amyotrophic lateral sclerosis\uff09\u306e\u7565\u3002\u795e\u7d4c\u5909\u6027\u75be\u60a3\uff08\u6ce85\u3092\u53c2\u7167\uff09\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u4f53\u3092\u52d5\u304b\u3059\u7b4b\u8089\u304c\u840e\u7e2e\u3059\u308b\u96e3\u75c5\u3002<\/p>\n<p>\u6ce82. \u30b9\u30c8\u30ec\u30b9\u9846\u7c92<br \/>\n\u7d30\u80de\u304c\u30b9\u30c8\u30ec\u30b9\u306b\u3055\u3089\u3055\u308c\u305f\u969b\u306b\u3001\u6db2-\u6db2\u76f8\u5206\u96e2\uff08\u6ce83\u3092\u53c2\u7167\uff09\u306b\u3088\u3063\u3066\u4e00\u6642\u7684\u306b\u5f62\u6210\u3055\u308c\u308b\u7d30\u80de\u5185\u6db2\u6ef4\u3002\u4e3b\u306bmRNA\u3084RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u304b\u3089\u69cb\u6210\u3055\u308c\u3001\u7d30\u80de\u306e\u30b9\u30c8\u30ec\u30b9\u9069\u5fdc\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3002\u4e00\u65b9\u3067\u3001\u30b9\u30c8\u30ec\u30b9\u9846\u7c92\u306e\u7570\u5e38\u51dd\u96c6\u3084\u5206\u89e3\u4e0d\u5168\u304c\u69d8\u3005\u306a\u75be\u60a3\u306e\u767a\u75c7\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u6ce83. \u6db2-\u6db2\u76f8\u5206\u96e2\uff08Liquid-liquid phase separation, LLPS\uff09<br \/>\n\u5747\u4e00\u306a\u751f\u4f53\u5206\u5b50\u306e\u6c34\u6eb6\u6db2\u304c\u3001\u751f\u4f53\u5206\u5b50\u304c\u9ad8\u6fc3\u5ea6\u3067\u5b58\u5728\u3059\u308b\u6db2\u76f8\uff08\u6db2\u6ef4\uff09\u3068\u5e0c\u8584\u306a\u6db2\u76f8\u306e\u4e8c\u76f8\u306b\u5206\u96e2\u3059\u308b\u73fe\u8c61\u3002<\/p>\n<p>\u6ce84. \u30e9\u30de\u30f3\u9855\u5fae\u93e1<br \/>\n\u7269\u8cea\u306b\u5149\u3092\u7167\u5c04\u3059\u308b\u3068\u3001\u5149\u3068\u7269\u8cea\u304c\u76f8\u4e92\u4f5c\u7528\u3092\u8d77\u3053\u3059\u3053\u3068\u3067\u6563\u4e71\u304c\u8d77\u3053\u308b\u3002\u6563\u4e71\u5149\u306e\u307b\u3068\u3093\u3069\u306f\u5165\u5c04\u5149\u3068\u540c\u3058\u6ce2\u9577\u3092\u6301\u3064\u30ec\u30a4\u30ea\u30fc\u6563\u4e71\u5149\u3067\u3042\u308b\u304c\u3001\u3054\u304f\u4e00\u90e8\u3001\u7269\u8cea\u4e2d\u306e\u5206\u5b50\u306e\u632f\u52d5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u5165\u5c04\u5149\u3068\u7570\u306a\u308b\u6ce2\u9577\u3092\u6301\u3064\u30e9\u30de\u30f3\u6563\u4e71\u5149\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u30e9\u30de\u30f3\u6563\u4e71\u5149\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u5dee\u304b\u3089\u3001\u5206\u5b50\u306e\u69cb\u9020\u3092\u89e3\u6790\u3059\u308b\u624b\u6cd5\u3092\u30e9\u30de\u30f3\u5206\u5149\u6cd5\u3068\u547c\u3073\u3001\u3053\u306e\u624b\u6cd5\u3092\u9855\u5fae\u93e1\u4e0b\u3067\u884c\u3044\u3001\u5fae\u5c0f\u306a\u9818\u57df\u306e\u5206\u5b50\u306e\u60c5\u5831\u3092\u5f97\u308b\u6280\u8853\u3092\u30e9\u30de\u30f3\u9855\u5fae\u93e1\u3068\u3044\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3010\u8ad6\u6587\u60c5\u5831\u3011<\/p>\n<p>\u30bf\u30a4\u30c8\u30eb\uff1aNucleic Acid-Rich Stress Granules Are Not Merely Crowded Condensates: A Quantitative Raman Imaging Study<br \/>\n\u8457\u8005\uff1a <strong>Ren Shibuya<\/strong>, Shinji Kajimoto*, Hideyuki Yaginuma, Tetsuro Ariyoshi,<br \/>\nYasushi Okada, Takakazu Nakabayashi*<br \/>\n*\u8cac\u4efb\u8457\u8005\uff1a\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1 \u51c6\u6559\u6388 \u68b6\u672c\u771f\u53f8\u3001\u540c\u6559\u6388 \u4e2d\u6797\u5b5d\u548c<br \/>\n\u63b2\u8f09\u8a8c\uff1aAnalytical Chemistry<br \/>\nDOI\uff1a<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.analchem.4c01096\">10.1021\/acs.analchem.4c01096<\/a><\/p>\n<p><a href=\"https:\/\/www.pharm.tohoku.ac.jp\/file\/information\/20241023.pdf\"><\/a><a href=\"https:\/\/www.tohoku.ac.jp\/japanese\/newimg\/pressimg\/tohokuuniv-press20241023_02_cell.pdf\">\u8a73\u7d30\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u672c\u6587\uff09<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":0,"template":"","news_cat":[5,7],"class_list":["post-518","news","type-news","status-publish","hentry","news_cat-news","news_cat-news_press"],"_links":{"self":[{"href":"https:\/\/web.tohoku.ac.jp\/diare\/wp-json\/wp\/v2\/news\/518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.tohoku.ac.jp\/diare\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/web.tohoku.ac.jp\/diare\/wp-json\/wp\/v2\/types\/news"}],"wp:attachment":[{"href":"https:\/\/web.tohoku.ac.jp\/diare\/wp-json\/wp\/v2\/media?parent=518"}],"wp:term":[{"taxonomy":"news_cat","embeddable":true,"href":"https:\/\/web.tohoku.ac.jp\/diare\/wp-json\/wp\/v2\/news_cat?post=518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}