{"id":349,"date":"2021-12-01T14:03:00","date_gmt":"2021-12-01T05:03:00","guid":{"rendered":"https:\/\/web.tohoku.ac.jp\/KineticControl\/?post_type=area-actives&#038;p=349"},"modified":"2021-12-15T13:05:51","modified_gmt":"2021-12-15T04:05:51","slug":"2021-12-1","status":"publish","type":"area-actives","link":"https:\/\/web.tohoku.ac.jp\/KineticControl\/area-actives\/2021-12-1\/","title":{"rendered":"2021\/12\/1 \u7b2c44\u56de\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09\u3067\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u3092\u958b\u50ac\u3057\u307e\u3057\u305f\u3002"},"content":{"rendered":"\n<p><a href=\"https:\/\/www2.aeplan.co.jp\/mbsj2021\/\">\u7b2c44\u56de\u5206\u5b50\u751f\u7269\u5b66\u4f1a\u5e74\u4f1a\uff08\u6a2a\u6d5c\uff09<\/a>\u3067\u3001\u9f4b\u5c3e\u3001\u5965\u6751\u304c\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u300c\u30bf\u30f3\u30d1\u30af\u8cea\u4f1a\u5408\u306e\u65b0\u5c55\u958b\u300d\u3092\u958b\u50ac\u3057\u307e\u3057\u305f\u3002\u540c\u30ef\u30fc\u30af\u30b7\u30e7\u30c3\u30d7\u3067\u3001\u9f4b\u5c3e\u3001\u5965\u6751\u3001\u6751\u5ca1\u304c\u767a\u8868\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<ul><li>\u9f4b\u5c3e\u667a\u82f1\u300c\u591a\u91cf\u4f53\u5f62\u6210\u3092\u4ecb\u3057\u305f\u30b7\u30e3\u30da\u30ed\u30f3\u306e\u6a5f\u80fd\u5236\u5fa1 \uff08Functional modulation of molecular chaperones by oligomerization\uff09\u300d\u3001\u53e3\u982d\u30fb\u62db\u5f85<\/li><\/ul>\n\n\n\n<ul><li>\u5965\u6751\u6b63\u6a39\u300cPDI family\u306e\u52d5\u7684\u306a\u4f1a\u5408\u306b\u3088\u308b\u5c0f\u80de\u4f53\u5185\u30bf\u30f3\u30d1\u30af\u8cea\u54c1\u8cea\u7ba1\u7406\u306e\u7406\u89e3\uff08Elucidating the ER protein quality control mechanism by assembled PDI family, the ER resident enzyme\/chaperones\uff09\u300d\u3001\u53e3\u982d\u30fb\u62db\u5f85<\/li><\/ul>\n\n\n\n<ul><li>\u6751\u5ca1\u8cb4\u535a\u300c\u5408\u6210\u5316\u5b66\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308b\u30b8\u30b9\u30eb\u30d5\u30a3\u30c9\u7d50\u5408\u7570\u6027\u5316\u9175\u7d20\u306e\u6a21\u5023\uff08Synthetic Mimics of Protein Disulfide Isomerase\uff09\u300d\u3001\u53e3\u982d\u30fb\u62db\u5f85<\/li><\/ul>\n\n\n\n<ul><li>\u91d1\u6751\u9032\u543e\u3001\u8c37\u5ddd\u96c4\u54c9\u3001\u4f0a\u85e4\u5927\u3001\u6797\u96e8\u66e6\u3001\u677e\u5d0e\u5143\u7d00\u3001\u9ed2\u6728\u559c\u7f8e\u5b50\u3001\u5c71\u53e3\u5b8f\u3001\u524d\u4ef2\u52dd\u5b9f\u3001\u674e\u6620\u660a\u3001\u7a32\u8449\u8b19\u6b21\u3001\u5965\u6751\u6b63\u6a39\u300cCa2+\u306b\u3088\u308bERp57-CNX\u8907\u5408\u4f53\u306e\u69cb\u9020\u6a5f\u80fd\u8abf\u7bc0\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\uff08Understanding the mechanism by which Ca2+ regulates ERp57-CNX complex formation\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<ul><li>\u65b0\u7d0d\u7fd4\u609f\u3001\u91d1\u6751\u9032\u543e\u3001\u5c71\u53e3\u5b8f\u3001\u65e5\u9ad8\u96c4\u4e8c\u3001\u7a32\u8449\u8b19\u6b21\u3001\u5965\u6751\u6b63\u6a39\u300cPDI\u30d5\u30a1\u30df\u30ea\u30fc\u9175\u7d20\u306b\u3088\u308b\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u9178\u5316\u7684\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u89e6\u5a92\u6a5f\u69cb\u306e\u89e3\u660e\uff08Understanding the mechanism by which PDI family members promote the oxidative protein folding of a precursor protein\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<ul><li>\u53e4\u5ddd\u862d\u3001\u91d1\u6751\u9032\u543e\u3001\u5c71\u53e3\u5b8f\u3001\u674e\u6620\u660a\u3001\u5965\u6751\u6b63\u6a39\u300c\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u89e3\u9175\u7d20\u306b\u3088\u308b\u57fa\u8cea\u5206\u89e3\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\uff08Elucidating the degradation mechanism by insulin degrading enzyme\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<ul><li>\u95a2\u51ea\u6c99\u3001\u91d1\u6751\u9032\u543e\u3001\u8352\u4e95\u5805\u592a\u3001\u5c71\u53e3\u5b8f\u3001\u7a32\u8449\u8b19\u6b21\u3001\u5965\u6751\u6b63\u6a39\u300c\u30d7\u30ed\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u4e2d\u9593\u4f53\u306e\u7406\u89e3\uff08Characterization of proinsulin folding intermediates along its folding pathway\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<ul><li>\u5ca1\u7530\u8389\u5948\u3001\u91d1\u6751\u9032\u543e\u3001\u9ed2\u4e95\u90a6\u5de7\u3001\u677e\u5d0e\u5143\u7d00\u3001\u9f4b\u5c3e\u667a\u82f1\u3001\u5c71\u53e3\u5b8f\u3001\u4f0a\u85e4\u5927\u3001\u674e\u6620\u660a\u3001\u4e2d\u6797\u5b5d\u548c\u3001\u7a32\u8449\u8b19\u6b21\u3001\u5965\u6751\u6b63\u6a39\u300c\u9178\u5316\u9084\u5143\u5236\u5fa1\u306b\u3088\u308b\u30d2\u30c8\u30ac\u30ec\u30af\u30c1\u30f31\u306e\u69cb\u9020\u6a5f\u80fd\u8abf\u7bc0\u306e\u7406\u89e3\uff08Understanding the role of redox-regulated galectin-1 function\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<ul><li>\u5ddd\u8d8a \u8061\u4e00\u90ce\u3001\u677e\u5d0e \u5143\u7d00\u3001\u77f3\u68ee\u6d69\u4e00\u90ce\u3001\u9f4b\u5c3e\u667a\u82f1\u300c\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3092\u5236\u5fa1\u3059\u308b\u8ee2\u5199\u56e0\u5b50Heat shock factor1\u306e\u9178\u5316\u9084\u5143\u4f9d\u5b58\u7684\u306a\u76f8\u8ee2\u79fb \uff08Redox-dependent phase transition mechanism of Heat shock factor 1\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<ul><li>\u5ca1\u7530\u8389\u5948\u3001\u91d1\u6751\u9032\u543e\u3001\u9ed2\u4e95\u90a6\u5de7\u3001\u677e\u5d0e\u5143\u7d00\u3001\u9f4b\u5c3e\u667a\u82f1\u3001\u5c71\u53e3\u5b8f\u3001\u4f0a\u85e4\u5927\u3001\u674e\u6620\u660a\u3001\u4e2d\u6797\u5b5d\u548c\u3001\u7a32\u8449\u8b19\u6b21\u3001\u5965\u6751\u6b63\u6a39\u300c\u9178\u5316\u9084\u5143\u5236\u5fa1\u306b\u3088\u308b\u30d2\u30c8\u30ac\u30ec\u30af\u30c1\u30f31\u306e\u69cb\u9020\u6a5f\u80fd\u8abf\u7bc0\u306e\u7406\u89e3\uff08Understanding the role of redox-regulated galectin-1 function\uff09\u300d\u3001\u30dd\u30b9\u30bf\u30fc<\/li><\/ul>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" 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