IR absorption spectra of the OH stretching vibration (ν_OH) and its combination band with the intermolecular vibrations (ν_int) of jet-cooled phenol-H₂O and phenol-CH₃OH clusters in the S₁ state were measured by fluorescence detected IR depletion spectroscopy (FDIRS). A remarkable mode dependence in their anharmonic couplings was observed: (1) The ν_OH¹ν_int¹ ← ν_int¹ transition showed blue-shift from the ν_OH¹ ← 0⁰ transition when ν_int is the intermolecular stretching vibration (σ). (2) On the other hand, the transition showed a red-shift when ν_int is the intermolecular wagging mode (β₂). The observed shifts and anharmonic constants are discussed on the basis of the adiabatic potential curves which describe the coupling between the high-frequency ν_OH and the low-frequency intermolecular motions.